Download PDF: JAMA HealthspanLifespanGap_garmany_2024_oi_241395_1733259944.03263
Key Points
Question What is the healthspan-lifespan gap, representing the number of years burdened by disease, in men and women across the world?
Findings This cross-sectional study quantified healthspan-lifespan gaps among 183 World Health Organization member states. Globally, the mean healthspan-lifespan gap was 9.6 years, and women exhibited a mean 2.4-year larger gap than men, associated with a disproportionately larger burden of noncommunicable diseases in women.
Meaning These findings suggest that the healthspan-lifespan gap is a universal threat to healthy longevity.
Importance Health-adjusted life expectancy, a measure of healthy longevity, lags longevity gains, resulting in a healthspan-lifespan gap.
Objective To quantify the healthspan-lifespan gap across the globe, investigate for sex disparities, and analyze morbidity and mortality associations.
Design, Setting, and Participants This retrospective cross-sectional study used the World Health Organization (WHO) Global Health Observatory as the global data source and acquired national-level data covering all continents. The 183 WHO member states were investigated. Statistical analysis was conducted from January to May 2024.
Exposures Data represent 2 decades of longitudinal follow-up.
Main Outcomes and Measures Changes in life expectancy and health-adjusted life expectancy, as well as the healthspan-lifespan gap were quantified for all participating member states. Gap assessment was stratified by sex. Correlations of the gap with morbidity and mortality were examined.
Results The healthspan-lifespan gap has widened globally over the last 2 decades among 183 WHO member states, extending to 9.6 years. A sex difference was observed with women presenting a mean (SD) healthspan-lifespan gap of 2.4 (0.5) years wider than men (P < .001). Healthspan-lifespan gaps were positively associated with the burden of noncommunicable diseases and total morbidity, and negatively with mortality. The US presented the largest healthspan-lifespan gap, amounting to 12.4 years, underpinned by a rise in noncommunicable diseases.
Conclusions and Relevance This study identifies growing healthspan-lifespan gaps around the globe, threatening healthy longevity across worldwide populations. Women globally exhibited a larger healthspan-lifespan gap than men.